INCREASED THE DISSOLUTION RATE AND SOLUBILITY OF CLOPIDOGREL BISULFATE ORODISPERSIBLE TABLETS
نویسندگان
چکیده
منابع مشابه
Formulation and Evaluation of Clopidogrel Bisulfate Immediate Release Tablets
Many patients especially children and elderly have difficulty in swallowing tablets and capsules and consequently unable to take medicine as prescribed. Almost 50% of the population is affected by such problem, resulting in the high incidence of non compliance and ineffective therapy. Most pharmaceutical forms for oral administration are formulated for direct ingestion, or for chewing, or for p...
متن کاملEffect of β Cyclodextrin Complexation on the Solubility and Dissolution Rate of Carbamazepine from Tablets
Carbamazepine was complexed with β-cyclodextrin in an attempt to enhance the solubility features of the drug. Phase solubility studies revealed a linear relationship between carbamazepine solubility and β-cyclodextrin concentration. The 3value of the stability constant (405.42 M) calculated from the phase solubility diagram indicated that the complexes were adequately stable. Carbamazepine-β-cy...
متن کاملSolubility and Dissolution Rate Enhancement of Olmesartan Medoxomil by Complexation and Development of Mouth Dissolving Tablets
The main objective of the research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with -Cyclodextrins. The inclusion complexes were prepared by kneading method. The prepared complexes were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Differential Scanning Calorimetry (DSC). The FTIR and XRD spectra o...
متن کاملEnhanced Solubility and Dissolution Rate of Raloxifene using Cycloencapsulation Technique
The aim of this study was to improve the water solubility of raloxifene by complexing it with sulphobutylether-β-cyclodextrin. Inclusion complexation in aqueous solution and solid state was evaluated by the phase solubility diagram, powder X-ray diffractometer, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, scanning electron microscopy, hot stage microscopy and transmissio...
متن کاملEffect of Binders on the Dissolution Rate and Dissolution Efficiency of Ritonavir Tablets
Ritonavir, a widely prescribed anti-retroviral drug, belongs to Class II under 'BCS' and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Ritonavir is practically insoluble in water and aqueous fluids. Its aqueous solubility was reported to be 2.56 mg/100 ml. As such oral absorption of ritonavir is dissolution rate limited and it requires enhancement in solubili...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Education and Research
سال: 2021
ISSN: 2278-7496
DOI: 10.38164/ajper/10.1.2021.96-109